ABSTRACT
An 8-year-old boy was admitted into the hospital with symptoms of anuria after consumption of 12 djenkol beans. Laparotomy showed a urethral calculus, size 2.0 x 0.4 cm, which was found to contain djenkolic acid 65 gm/100 gm stone with a small amount of protein, sodium, potassium and uric acid. This calculus contained no calcium, magnesium, phosphorus, ammonium salt, oxalate, carbonate, cystine and fibrin. The solubility of L-djenkolic acid in urine at 37 degrees C was found to be pH dependent, i.e., the higher the pH, the increase in solubility of djenkolic acid. D-pencillamine also showed similar effect, increasing the solubility of L-djenkolic acid in the urine at pH 5.7 in vitro. The cause and mechanism of formation of djenkolic acid crystals and calculi were discussed.
Subject(s)
Animals , Child , Fabaceae/adverse effects , Humans , Hydrogen-Ion Concentration , Male , Plants, Medicinal , Urinary Calculi/chemically inducedABSTRACT
Blood loss caused by A. ceylancium was determined in 13 dogs using 51Cr-labelled red cells. Blood loss was first detected in the faeces on the 10th to 13th day after cutaneous and 8th to 16th day after oral infection respectively. The mean blood loss was found to be 0.033 ml/worm/day and 0.038 ml/worm/day in these 2 groups of dogs respectively. There was a direct relationship between the number of worm and the amount of blood loss. The blood loss expressed as ml per worm per day showed a reverse relationship with the number of worms recovered. Considering a large amount of blood loss and the decrease in haematological values in these dogs, A. ceylanicum should be considered as one of the hookworm species of medical importance.